Finally, we applied BATMAN-TCM to Qishen Yiqi dripping Pill (QSYQ) and combined with subsequent experimental validation to reveal the functions of renin-angiotensin system responsible for QSYQ's cardioprotective effects for the first time. Its main functions include 1) TCM ingredients' target prediction 2) functional analyses of targets including biological pathway, Gene Ontology functional term and disease enrichment analyses 3) the visualization of ingredient-target-pathway/disease association network and KEGG biological pathway with highlighted targets 4) comparison analysis of multiple TCMs. Here we developed the first online Bioinformatics Analysis Tool for Molecular mechANism of TCM (BATMAN-TCM). However, owing to the TCM's diverse ingredients and their complex interaction with human body, it is still quite difficult to uncover its molecular mechanism, which greatly hinders the TCM modernization and internationalization. And TCM-based new drug development, especially for the treatment of complex diseases is promising. Traditional Chinese Medicine (TCM), with a history of thousands of years of clinical practice, is gaining more and more attention and application worldwide.
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